Biomimetic gradient scaffold from ice-templating for self-seeding of cells with capillary effect

A Biomimetic Compressed Collagen Scaffold for Cultured Limbal Epithelial Cells

Galway, Ireland A Biomimetic Compressed Collagen Scaffold for Cultured Limbal Epithelial Cells Hannah J Levis, Robert A Brown, Frank Tully, Julie Daniels. Corresponding Author: [email protected] Ocular Biology & Therapeutics, UCL Institute of Ophthalmology, London, United Kingdom; UCL Tissue Regeneration and Engineering Centre, London, United Kingdom; The Automation Partnership, Hertfordshire, ...

Cytotoxicity of Chitosan Derived from Shrimp for Bone Scaffold on Adipose Tissue-Derived Mesenchymal Stem Cells

Biomimetic Scaffold with Aligned Microporosity Designed for Dentin Regeneration

Tooth loss is a common result of a variety of oral diseases due to physiological causes, trauma, genetic disorders, and aging and can lead to physical and mental suffering that markedly lowers the individual's quality of life. Tooth is a complex organ that is composed of mineralized tissues and soft connective tissues. Dentin is the most voluminous tissue of the tooth and its formation (dentino...

Tumor Self-Seeding by Circulating Cancer Cells

Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is thought that this is a unidirectional process. Here we show that circulating tumor cells (CTCs) can also colonize their tumors of origin, in a process that we call "tumor self-seeding." Self-seeding of breast cancer, colon cancer, and melanoma tumors in mice is preferentially mediated by aggressive CTCs, ...

A G-CSF functionalized scaffold for stem cells seeding: a differentiating device for cardiac purposes

Myocardial infarction and its consequences represent one of the most demanding challenges in cell therapy and regenerative medicine. Transfer of skeletal myoblasts into decompensated hearts has been performed through intramyocardial injection. However, the achievements of both cardiomyocyte differentiation and precise integration of the injected cells into the myocardial wall, in order to augme...